“One of the more important aspects in brain metabolism is the cerebrospinal fluid (CSF) circulation. CSF is a brain fluid secreted as an ultrafiltrate by the choroid plexus. It has a very intricate physiology and is involved in hydrodynamic, metabolic and immunological aspects. The pathophysiology of CSF is equally complex and one of the main problems is hydrocephalus, defined as a dynamic imbalance between the production and absorption of CSF. The aetiology of hydrocephalus includes different pathologies affecting both production and resorption of CSF.
CSF has multiple functions as a mechanical protection of the brain maintaining electrolytic environments, as well as providing nutrient support to neural and glial cells. It also has a role in the lymphatic system although this is less well understood.
Our team is deeply involved in research of the phenomena underlying solute pathways in the cerebrospinal fluid and interstitial fluid of the central nervous system.
It also has a key role in the management of these pathologies in collaboration with other neurosurgical departments, with a particular focus on improving diagnosis, follow-up and treatment results.”
Alin BORHA, MD; Evelyne EMERY, MD, PhD. Caen University Hospital.